| abstract |
The invention provides a class has the hydroxycinnamic acid amine alkaloid of structure shown in following formula or its physiologically acceptable salt, crystalline hydrate or solvate, and its production and use.Described hydroxycinnamic acid amine alkaloid has the activity for suppressing people's COMT enzymes, can be used with levodopa simultaneously, reduce metabolism of the COMT enzymes to levodopa, so as to lift the bioavailability of levodopa. |