http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104277029-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 |
| filingDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104277029-B |
| titleOfInvention | Acridine-1,2,3-triazoles compounds and its preparation method and application |
| abstract | The invention discloses a kind of acridine-1,2,3-triazoles compounds and its preparation method and application.The preparation of described acridine-1,2,3-triazoles compounds comprises: 1) with o-bromobenzoic acid and P-nethoxyaniline for raw material, salt of wormwood and copper powder are catalyzer, with primary isoamyl alcohol or Pentyl alcohol for solvent, obtain compound 1 through ullmann reaction; 2) compound 1 closes ring with phosphorus oxychloride and obtains compound 2; 3) getting compound 2 is dissolved in DMF, carries out nucleophilic substitution reaction obtain compound 3 with sodiumazide; 4) get and be dissolved in butanol/water solution Methoxy-phenylacetylene, add sodium ascorbate, cupric sulfate pentahydrate and compound 3 and react, suction filtration, recrystallization, to obtain final product.Antitumor activity in vitro result shows that it has significant anti tumor activity in vitro to MGC80-3, BEL-7404 and T24 tri-kinds is tested, has good potential pharmaceutical use, is expected to the preparation for various antitumor drug. |
| priorityDate | 2014-09-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 51.