http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104276994-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-34 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-405 |
| filingDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104276994-B |
| titleOfInvention | 3,3 ' disubstituted Oxoindoles and 3 ethylene linkage Oxoindoles splicing derivative and preparation method and application |
| abstract | The invention discloses a kind of 3, 3 ' disubstituted Oxoindoles and 3 ethylene linkage Oxoindoles splicing derivative and preparation method and application, the present invention is placed in organic solvent with corresponding 3 substitution Oxoindole and Morita Baylis Hillman carbonic esters derived from isatin, directly it is catalyzed in base catalyst and is substituted elimination reaction, synthesize 3, 3 ' disubstituted Oxoindoles and 3 ethylene linkage Oxoindoles splicing derivative, the analog derivative includes potential bioactivity pyrrole skeleton and 3, the disubstituted Oxoindole skeletons of 3', chemical combination material resource can be provided for bioactivity screening, screening and pharmaceutical industry to medicine have important application value, the present invention is for these derivatives to three kinds of tumor cell line such as human prostates（PC‑3）, human lung carcinoma cell（A549）And human leukemia cell（K562）The tumor growth inhibiting activity screening for being carried out.These derivatives find there is certain suppression tumor cell growth activity, it is contemplated that used as antineoplastic use. |
| priorityDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 84.