http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104262340-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-14 |
| filingDate | 2014-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104262340-B |
| titleOfInvention | A kind of preparation method of Tadalafei |
| abstract | The invention belongs to pharmaceutical technology field, be specifically related to the preparation method of a kind of Tadalafei.This preparation method includes: (1R, 3R) 1,2; 3,4 tetrahydrochysene 2 chloracetyl 1 (3.4 methylenedioxyphenyl) 9 H pyridos (3,4 b) indoles 3 carboxylate methyl ester (1R; 3R) 1; 2,3,4 tetrahydrochysene 2 chloracetyls 1 (3; 4 methylenedioxyphenyls) 9H pyrido [3; 4 b] the temperature control reaction in N, N dimethylformamide of indoles 3 carboxylate methyl ester and methylamine water solution, obtain Tadalafei crude product with solvent washing after adding pure water crystallizationï¼›After 4 Tadalafei crude products are dissolved in N, N dimethylformamide, after recrystallizing with solvent and pure water, obtain Tadalafei sterling.The method drastically increases Tadalafei yield, easy operation, reduces the consumption of organic solvent, is suitable to industrialized production. |
| priorityDate | 2014-09-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.