http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104262318-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D313-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D313-12 |
| filingDate | 2014-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104262318-B |
| titleOfInvention | A kind of preparation method of Olopatadine hydrochloride |
| abstract | That the present invention relates to is the preparation method of compound Olopatadine hydrochloride, specifically with 2-chloromethyl benzoic acid methyl esters and p-hydroxyphenylaceticacid methyl esters for starting raw material, pass through etherificate, hydrolysis, cyclization, synthetic hydrochloric acid Olopatatadine is carried out again through wittig reaction and salify, this technological reaction mild condition, polyphosphoric acid is replaced with acetic anhydride, hydrochloric acid organic solvent is adopted effectively to realize splitting to Z/E type Olopatatadine, obtain Olopatadine hydrochloride, E by product effectively achieves the conversion of Z/E configuration through concentrated hydrochloric acid process, improve the yield of Olopatadine hydrochloride, good product purity, substantially increase the feasibility of suitability for industrialized production. |
| priorityDate | 2014-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 63.