| abstract |
The present invention relates to diol compound (II) or S-diol compound (II') in the mixed solvent of C 4 -C 7 ketone solvent and water, under alkaline condition, with arylsulfonyl chloride or alkyl Sulfonyl chloride reaction cyclization gives citalopram and S-citalopram. The solvent used in the invention has high solubility to reactants and products, thus reducing the amount of solvent used and improving production capacity, and at the same time, the post-treatment extraction effect is good and the operation is simple and convenient. |