| abstract |
The invention discloses a 5-phenylnicotinamide Bcr-Abl inhibitor and its preparation method and application. The structural formula of the compound is Among them, R 1 is morpholinyl, cyclopropylamino, diisopropylamino, diethylamino, isopropylamino or N,N-dimethylethylenediamine group, R 2 is mono Substituent or double substituent, substituent is tertiary amine, halogen. The series of inhibitors have a certain inhibitory effect on ABL1 kinase in vitro, and can inhibit the proliferation of tumor cell K562, and can be used for the preparation of antitumor drugs, especially CML (chronic myelogenous leukemia) drugs. The preparation method of the 5-phenylnicotinamide Bcr-Abl inhibitor provided by the invention has the advantages of easy-to-obtain raw materials, mild reaction conditions, simple operation of the reaction process and cheap reagents used. |