| abstract |
The invention relates to a compound which takes 5,7-dihydroxyanthraquinone [2,1-d]thiazole as a mother nucleus, which has a following general formula, and relates to a preparation method and an application of the compound in an antitumor drug. The compound takes a traditional natural product rheinic acid as an initial raw material, and a series of compound with high antineoplastic activity is synthesized through mild reaction condition. The antitumor activity in vitro of the preferable compound is stronger by more than 30 times by comparing with rheinic acid. |