http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104232640-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-02 |
| filingDate | 2014-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-10-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104232640-B |
| titleOfInvention | A kind of siRNA molecule suppressing Smad4 gene expression and application thereof |
| abstract | The invention discloses a kind of siRNA molecule suppressing Smad4 gene expression and application thereof.The sequence of described Double-stranded siRNA molecules is: positive-sense strand: 5 ' GCUGUCCUAUUGUAACUGUdtdt 3 ', antisense strand: 5 ' ACAGUUACAAUAGGACAGCdtdt 3 '.Described Double-stranded siRNA molecules can be used for the medicine of the preparation treatment joint disease relevant to joint fibrosis, such as, can be used for the medicine of preparation treatment congealed shoulder.The siRNA molecule of the present invention can specifically be combined with the mRNA coding region complementary series of Smad4 gene, by the efficiently reticent Smad4 mRNA of degraded mRNA, thus Smad4 gene expression is carried out post-transcriptional control, the change of Smad4 expression directly influences TGF β/Smad4 path, thus increment fibroblastic on joint and fibrosis produce impact, finally the treatment on joint diseases relevant to joint fibrosis such as congealed shoulders produces and actively affects. |
| priorityDate | 2014-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 740.