| abstract |
The present invention relates to gastrodin ferulic acid ester compounds and their preparation method and application, effectively solving the problem of combining gastrodin ferulic acid to produce gastrodin ferulic acid ester compounds, and preparing, improving and treating neurasthenia and neurasthenia syndrome And the medication problem of angioneurotic headache, the method is, carry out acetylation with acetic anhydride to anhydrous glucose, then hemiacetal hydroxy bromide, then condense with p-hydroxybenzaldehyde, hydrogenation reduction, get acetylgastrodin, ferulae Acid hydroxy acetylation protection to obtain 3-(4'-acetyl-3'-methoxyphenyl)-2-acrylic acid, and then prepare acetylferuloyl chloride; dissolve acetylgastrodin in a dry solvent, add nucleophilic An acylation catalyst and an acid-binding agent; acetyl feruloyl chloride is dissolved in a dry solvent, and the two solutions are mixed to obtain ester compounds, and then deacetylated under alkaline conditions to obtain gastrodin ferulic acid ester compounds; the present invention The gastrodin ferulic acid ester compounds have the effects of sedation, hypnosis, and improvement of blood circulation in the brain. |