| abstract |
The invention relates to synthesis of dihydropyrazol sulfonamide derivatives containing benzodioxane skeletons. The synthesis is characterized by being provided with a general formula shown in descriptions. The dihydropyrazol sulfonamide derivatives containing the benzodioxane skeletons play an obvious role in inhibiting human mammary cancer cells (MCF-7), cervical carcinoma cells (HeLa), lung cancer cells (A549), liver cancer cells (HepG2) and matrix metalloproteinase-2 (MMP-2), and meanwhile, show cell toxicity, which is equivalent to or better than that of positive control drugs, to human kidney epithelial cells (293T). Thus, the dihydropyrazol sulfonamide derivatives containing the benzodioxane skeletons can be applied to the preparation of anti-tumor drugs. The invention discloses a preparation method and anti-tumor bioactivity of the dihydropyrazol sulfonamide derivatives containing the benzodioxane skeletons. |