| abstract |
The invention discloses a synthetic method of azoxystrobin, which comprises 4,6-dichloropyrimidine and 2-(2-hydroxyphenyl)-3,3-dimethoxypropane under alkaline conditions and the presence of a catalyst. Acid methyl ester carries out coupling reaction in suitable solvent and obtains 2-[2-(6-chloropyrimidin-4-yloxygen) phenyl]-3,3-dimethoxypropionic acid methyl ester; Add 2- The reaction of hydroxybenzonitrile with a base or a salt of 2-hydroxybenzonitrile gives 2-[2-[6-(2-cyanophenoxy)pyrimidin-4-yloxy]phenyl]-3,3 - Methyl dimethoxypropionate; remove a molecule of methanol to obtain azoxystrobin. Or the 2-[2-(6-chloropyrimidin-4-yloxy)phenyl]-3,3-dimethoxypropionate methyl ester obtained by the reaction is first removed from a molecule of methanol, and then combined with 2-hydroxy The reaction of benzonitrile with alkali or salt of 2-hydroxybenzonitrile gives azoxystrobin. The invention uses a newly designed catalyst, can make the reaction proceed in the organic phase or in the oil-water two-phase, simplifies the separation and post-treatment process, and is suitable for large-scale industrial production. |