http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104212821-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 |
| filingDate | 2014-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104212821-B |
| titleOfInvention | BCR ABL fusion protein mutants and its encoding gene, expression vector and its construction method and application |
| abstract | The invention provides a kind of BCR ABL fusion protein mutant code gene, its nucleotide sequence such as SEQ ID NO:Shown in 1, the expression vector comprising the nucleotide sequence and its construction method are additionally provided；A kind of BCR ABL fusion protein mutants are additionally provided, the mutant is designed based on BCR ABL/c ABL SH3 domains site mutations, L-Tyrosine is sported positioned at the ABL SH3 structures threonine of 79, its aminoacid sequence is SEQ ID NO:2.The BCR ABL fusion protein mutant competitive binding RIN1 of structure, directly block and reduce the combination of intracellular RIN1 and BCR ABL, joint IM effects, and then increase sensitivity of the cell to IM, promote apoptosis of tumor cells, while overcome. |
| priorityDate | 2014-07-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 79.