http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104211742-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-11 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 |
| filingDate | 2014-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2020-06-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104211742-B |
| titleOfInvention | Phosphoryl N-fatty acyl nucleoside analogues for the treatment of viral hepatitis and liver cancer |
| abstract | The invention discloses a phosphoryl N-fatty acyl nucleoside analogue for treating viral hepatitis and liver cancer, which is characterized in that the nucleoside analogue is modified by a cyclophosphamide group and then is connected with fatty chains with different carbon atoms. The phosphoryl N-fatty acyl nucleoside analogue can be conveniently prepared into a nano delivery system and has obvious liver cell targeting and tumor targeting. The nano delivery system comprises liposome, nonionic surfactant vesicles, nanoparticles, nanoemulsion and a self-assembly delivery system. The nucleoside drug is selected from lamivudine, vidarabine, cidofovir, gemcitabine, cytarabine, azacitidine, and fludarabine. After intravenous administration, the nanometer delivery system of the phosphoryl N-fatty acyl nucleoside analogue can exert the effect of treating viral hepatitis and liver cancer in a targeted way. |
| priorityDate | 2014-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 343.