http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104211731-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-6558 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-10 |
| filingDate | 2014-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104211731-B |
| titleOfInvention | Method for preparing high-purity voriconazole phosphate |
| abstract | The invention relates to a method for preparing high-purity voriconazole phosphate. The method comprises the following steps of 1, dissolving voriconazole and organic weak base in an organic solvent, dropwisely adding a phosphorus trichloride solution into the solution and then carrying out stirring at a room temperature for a reaction, 2, cooling the reaction system obtained by the step 1, carrying out a hydrolysis process on the ice-water mixture, and after hydrolysis, removing the organic solution by evaporation to obtain a voriconazole phosphate intermediate, and 3, dissolving the voriconazole phosphate crude product and inorganic weak base in water, dropwisely adding an oxidant aqueous solution into the solution, carrying out stirring in an ice bath for a reaction, carrying out filtration, and adjusting a pH value of the filtrate until a lot of solids are precipitated, wherein the filtered solid is the high-purity voriconazole phosphate. The method is simple and practical, has a high yield, less impurities and short reaction time, is free of a high-pressure hydrogenation reactor and palladium-carbon and is especially suitable for industrial production. The invention also relates to a use of the voriconazole phosphate intermediate as an antifungal drug. An experiment proves that voriconazole phosphate has a strong fungal infection-resistant capability. |
| priorityDate | 2013-06-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 66.