http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104211634-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_38a069878a700f280f8a98d1e45d7b2d |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D209-88 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D209-88 |
| filingDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fb46b517999e185888d33af009733c2d |
| publicationDate | 2014-12-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104211634-A |
| titleOfInvention | A kind of synthetic method of 2-bromocarbazole |
| abstract | The invention discloses a synthesis method of 2-bromocarbazole. The synthesis method is as follows: taking o-iodonitrobenzene, 4-bromophenylboronic acid, and potassium carbonate are added to DME/water solution and degassed, and Pd is added under nitrogen protection. (PPh3)4 reaction, reflux, lowered to room temperature, phase separation to obtain the organic phase, dried with anhydrous sodium sulfate and vacuum distillation, the resulting yellow oil was quickly passed through a silica gel column using ethyl acetate/hexane to separate 4-bromo-2 -Nitrobiphenyl; heat and stir 4-bromo-2-nitrobiphenyl, triethyl phosphite and o-dichlorobenzene under nitrogen protection, desolvate under reduced pressure until no liquid is evaporated, then add acetic acid Ethyl ester and water were washed, extracted, dried with anhydrous sodium sulfate, filtered, and the filtrate was rotary evaporated under vacuum, and the obtained crude product was quickly passed through silica gel to obtain off-white solid 2-bromocarbazole. The invention first separates 4-bromo-2-nitrobiphenyl, and then synthesizes 2-bromocarbazole, the synthesis process is simple and feasible, and the problems of high energy consumption, low yield and generation of three wastes are avoided. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-105061296-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-106117113-A |
| priorityDate | 2014-07-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.