http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104211604-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C65-03 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C51-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C215-44 |
| filingDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104211604-B |
| titleOfInvention | Eutectic of a kind of ambroxol and P-hydroxybenzoic acid and preparation method thereof |
| abstract | The invention belongs to pharmaceutical co-crystals technical field, be specifically related to a kind of novel ambroxol pharmaceutical co-crystals and preparation method thereof. The ambroxol pharmaceutical co-crystals space group that the present invention prepares is monoclinic system, two ambroxol molecules, and two P-hydroxybenzoic acid and a hydrone are by forming the elementary cell of ambroxol pharmaceutical co-crystals together with Hydrogenbond. The solvent that pharmaceutical co-crystals preparation process of the present invention is selected is the mixed solvent of first alcohol and water, and employing method is solvent room temperature volatility process, because the boiling point of selected solvent is relatively low, therefore crystal will be separated out in the process of solvent evaporates. Pharmaceutical co-crystals prepared by the present invention is outside the speciality such as the eliminating of the inner thick secretions of promotion respiratory tract and the delay of minimizing mucus of having inherited ambroxol, and stability is significantly improved. |
| priorityDate | 2014-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 38.