| abstract |
The present invention relates to the targeted drug delivery method of compound, the compound includes chemical agent, (more) peptide and the medicine based on nucleic acid (such as DNA vaccination, ASON, ribozyme, catalytic DNA (DNA ribozymes) or RNA molecule, siRNA encode its plasmid).And, outside the present invention relates to the blood vessel into cell, tissue and organ and intracellular target sites, target site targeted delivery of drugs compound particularly into central nervous system (CNS), into and through the method for blood-brain barrier, this method is realized by targetting the Glutathione Transport albumen being present on these cells, tissue and organ.In addition, compound or its pharmaceutically acceptable carrier are conjugated to the part based on glutathione, the part promotes to specifically bind these Glutathione Transport albumen and by these Glutathione Transport albumen internalizations. |