http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104203956-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0812 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K45-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-65 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-407 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 |
| filingDate | 2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104203956-B |
| titleOfInvention | For the thieno indole derivativeses of the functionalization for the treatment of cancer |
| abstract | The present invention relates to the formula (I) or the thieno indole derivativeses of (II) of new functionalization, which has cellular cytoxicity activity and is applied to treatment disease such as cancer and cell proliferation disorder.The invention further relates to purposes of the thieno indole derivativeses of these functionalization in conjugate is prepared.In formula (I) or (II), R 1 And R 2 Group (D) or (G), wherein R are formed together 5 It is hydrogen or C 1 ‑C 4 Alkyl；R 3 And R 4 It is independently hydrogen, C 1 ‑C 4 Alkyl or C 1 ‑C 4 Hydroxy alkyl；N is 0,1 or 2；Each X is independently O, S or NR 4 ‑；Each Y is independently CH=or N=；R 7 And R 8 It is independently hydrogen, halogen, hydroxyl, C 1 ‑C 4 Alkoxyl, cyano group, NHCOOR 3 、‑C(NH)NH 2 Or NR 3 R 4 , A is O, NH or CO；The structure division that L does not exist or conditionally can crack；W do not exist or can selfdecomposition structure division, which includes one or more can selfdecomposition group；Z does not exist or peptide, non-peptide or peptide and non-peptide mixed type linker；RM is not present or reactable structure division；R 6 It is leaving group；A 1 Do not exist or A, L 1 It is hydrogen or L. |
| priorityDate | 2012-04-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 234.