http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104193767-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D501-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-546 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D501-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-04 |
| filingDate | 2014-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104193767-B |
| titleOfInvention | A kind of cefamandole nafate superfine powder preparation and preparation method thereof |
| abstract | The preparation method of a kind of cefamandole nafate superfine powder preparation of disclosure: (1), reacted with thionyl chloride by benzoyl acetic acid, thionyl chloride is removed after terminating by reaction；(2), the product obtained is dissolved in dichloromethane, is then added thereto to 7-amino-3-[(1-methyl isophthalic acid H-tetrazolium-5-base) sulfidomethyl]-3-cephem-4-carboxylic acid again, after reaction, obtains compound (I)；(3), compound (I) is dissolved in oxolane, then wherein to entering sodium borohydride, after reaction, obtains compound (II): (4), compound (II) and formic acid are obtained by reacting compound Mandokef；(5), sodium salt is made；(6), dried comminution by gas stream become superfine powder, the particle diameter of superfine powder is 0.5 ~ 3 μm.This method simple in construction, and raw material is cheap, is beneficial to batch production. |
| priorityDate | 2014-08-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.