http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104188989-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_abd6657a425b37c42fe4b17b30c8bb72 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-513 |
| filingDate | 2007-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c7e285b3023883a54795c21edbbed4ab |
| publicationDate | 2014-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104188989-A |
| titleOfInvention | Composition and method for reducing drug levels in tissues when orotate derivative is given |
| abstract | The invention relates to the field of reconstruction of drug chemical structure by preparation of orotate derivatives, and the drug is known to have side effect to cause tissue toxicity. More specifically, the invention relates to anthracycline, doxorubicin and daunorubicin orotate derivatives, and the orotate derivatives which and can reduce drug levels in non cancer tissues. The orotate derivatives are equally effective in inhibiting animal SCCAKI-1 renal tumor, and compared with doxorubicin hydrochloride, doxorubicin reduction in heart tissue shows that toxicity induced by production of anthracycline free radicals is reduced. |
| priorityDate | 2007-08-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 112.