http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104151509-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-107 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F293-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-34 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-337 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08G63-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F8-12 |
| filingDate | 2014-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-02-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104151509-B |
| titleOfInvention | H-type pH-sensitive degradable block copolymer and preparation method and application thereof |
| abstract | The invention discloses an H-type pH-sensitive degradable block copolymer and a preparation method and application thereof. The copolymer consists of a pH-sensitive polymethylacrylic acid chain segment and a biodegradable polylactic acid chain segment. The preparation method comprises the following steps: firstly, preparing tetrachloropolylactic acid by hydroxyl-terminated polylactic acid and dichloroacetyl chloride; then, preparing an H-type tert-butyl methacrylate-lactic acid copolymer by virtue of atom transfer radical polymerization reaction of tert-butyl methacrylate; and carrying out acidic hydrolysis. The copolymer can be self-assembled to a spherical core-shell micelle with the clinical agglomeration concentration of 19.7-32.5mg/L and the hydrodynamic diameter being less than 200nm. The micelle shows pH sensitivity and biodegradability, and the degradation rate changes along with copolymer composition and environmental media. The micelle has a higher release rate on 10-hydroxycamptothecine and taxol in a buffer solution with the pH value of 5.6-7.4 than a buffer solution with the pH value of 1.4, and shows pH-dependent cytotoxicity. The micelle can be used as a carrier with a hydrophobic drug which is released in a targeted manner for targeted treatment of intestinal cancer. |
| priorityDate | 2014-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 56.