http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104151397-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e74277852f1aae0a3ff13f59a65456d |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-555 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07F9-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 |
| filingDate | 2014-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e715793bef414c71876d373d459cf116 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37c508783f3a2421ca62d22ec3ffaf46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34b35e1d7c242226e69fe066537a8cad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e2400d5e4850033dcd725fcf545588b |
| publicationDate | 2014-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104151397-A |
| titleOfInvention | A new type of trithiabicyclic organic arsenic compound and its synthesis method and application in the field of anti-tumor |
| abstract | The invention discloses a new class of organic arsenic compound 4-R-1-arsenic-2,6,7-trithiabicyclo[2.2.2]octane compound, its preparation method and its application in medicine. The present invention uses pentaerythritol as the starting material to obtain 3-bromo-2,2-dibromomethylpropanol through bromination reaction; then introduces a pre-designed chemical group at the hydroxyl position; then introduces a sulfur atom by using three halogen atoms , to obtain the key intermediate 2-R2-1,3-diacetylthio-2-acetylthiomethylpropane; on the basis of this intermediate, through several different methods, through different intermediates, the sulfur atom and arsenic Combining atoms to synthesize the target compound 4-R-1-arsenic-2,6,7-trithiabicyclo[2.2.2]octane, the substituent R- in the general formula of the target compound can be successfully derived into various Amino acid and peptide structures. The invention has the advantages of readily available raw materials, simple and convenient operation, low cost, diverse synthesis methods and the like. The compound of the invention shows good tumor cell killing effect in the in vitro cytotoxicity test, and is the first application of this type of compound in the field of antitumor. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-110101713-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9427483-B2 |
| priorityDate | 2014-07-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.