http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104151265-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10c3f12979e7751f6e54ae5594988766 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcaa03b795cd8da869d58e8f28bf52e5 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-088 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-088 |
| filingDate | 2013-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c1093800ce8ca6411fd6688c9d4b8603 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_699232252e1dfd1a5f52aa8f9d5b398e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f8b0ec4d305b9fdef05a46154a4bbba http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e2e6146bfcfe79aa8e33409dbbbbf7f6 |
| publicationDate | 2014-11-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104151265-A |
| titleOfInvention | The preparation method of bazedoxifene acetate intermediate |
| abstract | The invention discloses a preparation method of a bazedoxifene acetate intermediate. The invention provides a method for preparing an intermediate compound 3 of bazedoxifene acetate, which comprises the following steps: step (1): in a polar aprotic solvent, under the condition of the presence of a base, p-hydroxybenzaldehyde 6 and compound 5. Condensation reaction is carried out to obtain intermediate compound 4; step (2): the reaction solution obtained in step (1) is directly mixed with a protic solvent without post-treatment, and then carried out reduction reaction with a reducing agent to obtain intermediate compound 3 of bazedoxifene acetate . The preparation method of the present invention has short route, mild reaction conditions, safe operation, simple post-treatment process, high reaction conversion rate, high product yield, good purity, environment-friendly, and is suitable for industrialized production. |
| priorityDate | 2013-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 26.