| abstract |
The invention discloses a novel preparation method of (5R, 6S)-5,6-dephenyl -2-morpholinone (I). The novel preparation method comprises the following reaction steps: enabling (1S, 2S)-2-chloro-1, 2-diphenylethanol (II) to react with glycine to generate 2-[(1R, 2S)-2-hydroxyl-1,2-diphenylethylamino] acetic acid (III); salifying the compound (III) and acid to form 2-[(1R, 2S)-2-hydroxyl-1,2-diphenylethylamino] ethanoic acid salt (IV); and enabling the compound (IV) to be subjected to ring closing reaction under the action of a ring closing reagent to obtain (5R,6S)-5,6-dephenyl -2-morpholinone (I). |