http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104147612-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4745 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7068 |
| filingDate | 2014-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-05-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104147612-B |
| titleOfInvention | A small molecule targeting conjugate specifically activated by tumor microenvironment and its use |
| abstract | The invention discloses a small molecule targeting conjugate specifically activated by the tumor microenvironment and its application. The compound has the following general formula: Among them, R1 can be a conventional group or a special functional group, R2 is any amino acid in Thr, Val, Ile or Ala; R3 is any amino acid in Ala, Val, Thr, or Asn, and R4 is through The drug group connected by hydroxyl or amino group, the general formula of the drug is R4‑H. The use of the small molecule targeting conjugate specifically activated by the tumor microenvironment of the present invention can effectively block the toxicity of the conjugated drug R4, and then only use the targeted activation of asparagine endopeptidase in the tumor microenvironment to make the final drug carry With new targeting, activation and metabolic properties, it increases the effect of treating tumors, and produces new tumor indications and anti-tumor metastasis effects, resulting in a new structure and function. |
| priorityDate | 2014-08-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 22.