http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104130239-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-20 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-20 |
| filingDate | 2014-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104130239-B |
| titleOfInvention | The preparation method of Duloxetine chiral intermediate |
| abstract | The preparation method who the present invention relates to a kind of Duloxetine chiral intermediate (S)-N-methyl-3-hydroxyl-3-(2-thienyl)-1-propylamine, belongs to technical field of medicine synthesis. The present invention is under nitrogen protection; under the existence of chiral catalyst, mantoquita and alkali; trans-N-methyl-3-(2-thienyl)-crotonamide reacts with boron compound in solvent, and then product obtains (S)-N-methyl-3-hydroxyl-3-(2-thienyl)-1-propylamine through redox. The present invention is simple, and the target product yield of preparation is high, and optical purity is high, and purification difficulty is little, is applicable to amplifying producing studying. |
| priorityDate | 2014-08-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 85.