http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104130165-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C305-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C303-44 |
| filingDate | 2014-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104130165-B |
| titleOfInvention | A kind of moclobemide intermediate post-treating method |
| abstract | The invention discloses a kind of moclobemide intermediate post-treating method, it comprises, with second ammonia sulfuric ester, parachlorobenzoyl chloride for raw material, triethylamine is acid binding agent, toluene is solvent, moclobemide key intermediate is synthesized to chlorobenzamide ethylsulfuric acid ester at 0 ~ 5 DEG C, after reaction terminates, add the water of rear mixed solution 8 ~ 10 times amount of reaction, and mixed solution is risen to 30-35 DEG C, the solid of generation is all dissolved, stratification, organic layer toluene, is reclaimed toluene after being anhydrated apply mechanically by the distillation point of band water; Water layer is chilled to 15 ~ 20 DEG C of crystallization half an hour, centrifugal to dry, then uses the water washing of 1 ~ 2 times amount, centrifugal to dry, is dried to dry under 0.080 ~ 0.100MPa vacuum, 25 ~ 30 DEG C of conditions.Present invention achieves the high efficiente callback of toluene, improve the quality of products simultaneously, this invention has significant environmental benefit, economic benefit. |
| priorityDate | 2014-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 23.