| abstract |
The application provides heteroaryl pyridone and aza-pyridone compounds of formula I, wherein one or two of X 1 , X 2 and X 3 are N, and include stereoisomers and interconversions of the compounds Isomers and pharmaceutically acceptable salts for inhibiting Btk kinase and for treating immune disorders such as inflammation mediated by Btk kinase. The present application discloses methods of in vitro, in situ and in vivo diagnosis and treatment of said disorders or associated pathological conditions in mammalian cells using compounds of formula I. |