| abstract |
The invention discloses a new process for synthesizing progesterone. The process method uses (20S)-20-hydroxymethylpregn-4-en-3-one, a phytosterol fermentation product, as a starting material, and uses dimethyl sulfide Mixtures with N-chlorosuccinimide oxidize it. Then in the DMF solution of DBU and Cu(OAc) 2 .H 2 O and 2,2'-bipyridine, carry out oxidative decarboxylation reaction to prepare progesterone. The process is simple, the yield is high, up to 80%, the product quality is good, the raw material is easy to obtain, and the preparation cost is low. |