http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104109157-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-10 |
| filingDate | 2014-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-05-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104109157-B |
| titleOfInvention | The preparation method that Ka Gelie is clean |
| abstract | The present invention relates to the clean preparing technical field of Ka Gelie, particularly the clean preparation method of a kind of Ka Gelie<b>:</b>Generate compounds Ⅳ taking four pivaloyl groups-alpha-D-bromo glucopyranose as raw material with connection boric acid pinacol ester generation electrophilic substitution reaction; Taking the iodo-2-aminomethyl phenyl of 2-(4-fluorophenyl)-5-[(5-) methyl] thiophene as raw material under catalyst action with compounds Ⅳ reacting generating compound VI; Compound VI is hydrolyzed under alkali condition, and it is clean that Deprotection obtains Ka Gelie. The clean method of Ka Gelie of preparing of the present invention, synthetic route shortens dramatically, only have three steps, simplified operating procedure, reaction condition is comparatively gentle, post processing is simple and easy to do, be more suitable for industrialization production requirements, not only save production time and labour cost, and reduced production cost, the yield that has increased substantially reaction, this route total recovery reaches more than 60%. |
| priorityDate | 2014-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.