http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104101714-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6863 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-573 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-539 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2014-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104101714-B |
| titleOfInvention | To suppress the screening anti-tumor medicine method that Smurf1 ubiquitination degraded RhoB is target spot |
| abstract | To suppress the screening anti-tumor medicine method that Smurf1 ubiquitination degraded RhoB is target spot, relate to anticancer drug screening.Candidate compound is contacted with subject; Observe candidate compound to degrade on the described a kind of E3 of suppression ubiquitin ligase Smurf1 ubiquitination the impact of testing result of its substrate RhoB, if described candidate compound can make intracellular testing result generation negative sense change, namely characterize the reduced capability of Smurf1 ubiquitination degraded RhoB, then show that this candidate compound is antineoplastic potential drug.Describedly show that this candidate compound is after antineoplastic potential drug, the compound that can improve RhoB protein content in cancer cell can be selected further, its concrete grammar: contacted with dissimilar tumour cell by candidate compound; Observe candidate compound to the impact of RhoB protein content in dissimilar tumour cell.Experimental period is short, testing process is fast, highly sensitive, applied range. |
| priorityDate | 2014-07-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.