| abstract |
The present invention provides mouse monoclonal antibody or the fragment being made up of its functional fragment, the hybridoma of preserving number FERM BP 11446, FERM BP 11447, FERM BP 11448 or FERM BP 11449 monoclonal antibody produced or its functional fragment of the antigenic determinant identifying the Aggrus being made up of the aminoacid sequence shown in serial number 1,3 or 4.The present invention provides above-mentioned hybridoma, comprises said monoclonal antibody or Aggrus CLEC 2 binding inhibitors of fragment being made up of its functional fragment and for suppressing platelet aggregation or suppression cancerometastasis or disposing tumor or the medical composition of thrombotic disease. |