http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104086538-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2014-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104086538-B |
| titleOfInvention | Intermediate of a kind of PI3K inhibitors of kinases and preparation method thereof and application |
| abstract | The invention discloses intermediate of a kind of PI3K inhibitors of kinases and preparation method thereof and application, with compounds X I for raw material, be obtained by reacting compounds X II with isopropanolamine；Compounds X III is obtained then through oxidation reaction；Cyclization obtains compounds X IV in acid condition；It is obtained by reacting compounds X V under oxidative conditions；It is obtained by reacting compounds X VI with 1-isopropyl piperazine under reducing agent effect；Under alkali effect, it is obtained by reacting compounds X VII with benzene sulfonyl chloride；When alkali and catalyst with 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-base)-1<i>h</i>-indole reaction obtains compound I.Preparation method reaction selectivity of the present invention is high, simple to operate, and productivity is high, and total recovery is up to 78.6%, and higher than the total recovery in documents much and reaction condition is gentle, and process route is suitable for extensive preparation. |
| priorityDate | 2014-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 80.