http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104083395-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-734 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-702 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A23L33-125 |
| filingDate | 2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-07-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104083395-B |
| titleOfInvention | The application of marine source Oligoguluronic Acids |
| abstract | The present invention relates to biomedicine field, disclose the application of a kind of marine source Oligoguluronic Acids.The oligosaccharide MdOA that Algin oxidative degradation obtains can suppress the LPS RAW264.7 cell induced to produce excessive NO, and in concentration dependent.Present invention application RT-PCR method, it has been found that along with the increase of MdOA stimulation time, in RAW264.7 cell, the mRNA of iNOS and the COX-2 of overexpression reduces, in concentration dependent；Application Western Blot method finds, MdOA can suppress iNOS albumen and the overexpression of COX-2 albumen；Application ELISA method finds, MdOA can suppress the expression of the related inflammation cytokine such as TNF-α in cell, IL-6, IL-1 β.Therefore, marine source Oligoguluronic Acids MdOA can be applicable to prepare anti-inflammatory drug. |
| priorityDate | 2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 131.