| abstract |
The object of the present invention is to provide a compound represented by the following general formula (1) or a salt thereof, which acts on tubulin to have an anticancer effect and is highly safe and effective. (In the formula, Ar represents aryl or heteroaryl; Z 1 , Z 2 , Z 3 and Z 4 independently represent CH, nitrogen atom, oxygen atom or sulfur atom; R 1 represents hydrogen atom, halogen atom, alkyl etc.; R 2 and R 3 are the same or different, representing a hydrogen atom, a halogen atom, a carboxyl group, etc.; n R 4 are the same or different, representing a hydrogen atom, an alkyl group, etc.; n represents a number from 0 to 4.). |