http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104072617-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-62 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-15 |
| filingDate | 2013-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-09-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104072617-B |
| titleOfInvention | Porcine rotavirus Δ VP8 subunit restructuring chimeric protein and application thereof |
| abstract | The present invention relates to porcine rotavirus Δ VP8 subunit restructuring chimeric protein and application thereof, described restructuring chimeric protein is that the clipped form (OSU Δ VP8) of the clipped form (Gottfried Δ VP8) by tetanus toxin t cell epitope polypeptide P2 and porcine rotavirus Gottfried strain VP8 subunit and porcine rotavirus OSU strain VP8 subunit is chimeric to be formed, and connected by flexible Linker between tetanus toxin t cell epitope polypeptide P2, Gottfried Δ VP8 and OSU Δ VP8, contribute to the correct folding of restructuring chimeric protein, improve soluble protein yield.The porcine rotavirus Δ VP8 subunit restructuring chimeric protein that the present invention provides can the anti-class Gottfried type (G4P [6]) of induced high titers or class OSU type (the rotavirus neutralizing antibody that G5P [7] genotype is special, show that this restructuring chimeric protein has excellent immunogenicity, and the yield high (laboratory routine is prepared up to more than 20mg/L) of this solubility restructuring chimeric protein, it is suitable for industrialized production and the preparation of high-volume Novel pig Rotavirus Vaccine. |
| priorityDate | 2013-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 44.