| abstract |
The present invention relates to quinoline derivatives represented by general formula I and their pharmaceutically acceptable salts, hydrates, solvates and prodrugs, wherein the substituents R 1 , R 2 , X, Y, Z, n have the meaning given in the specification. The present invention also relates to compounds of general formula I having a strong inhibitory effect on c-Met kinase, and also relates to the preparation of such compounds and their pharmaceutically acceptable salts, hydrates, solvates or prodrugs for the treatment of c-Met The use of the medicine for diseases caused by abnormally high expression of kinases, especially the use in the preparation of medicines for treating and/or preventing cancer. |