http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104072426-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D239-94 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D239-94 |
| filingDate | 2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2017-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104072426-B |
| titleOfInvention | A kind of preparation method of cancer therapy drug |
| abstract | The invention discloses a kind of new synthetic method of cancer therapy drug Gefitinib.The present invention with 4 methoxyl group 5 (3 morpholine propoxyl group) 2 p-nitriles be raw material, through sodium hydrosulfite reduce and with hydrochloric acid into salt, again with DMF dimethylacetal reaction obtain condensation product after, then with the fluoroaniline of 3 chlorine 4 cyclization after Gefitinib.Initiation material selected by the present invention is inexpensively easy, and simplifies synthetic route, substantially increases raw material availability and gross production rate.Reaction gained intermediate is mostly purified with recrystallization method, or directly carries out next step reaction, and yield is high, and the three wastes that course of reaction is produced are few, with low cost to be conducive to industrial production. |
| priorityDate | 2013-03-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 64.