http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104045762-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-32 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08F220-26 |
| filingDate | 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-08-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104045762-B |
| titleOfInvention | A kind of RAFT method synthesis method containing the temperature sensitive copolymer of glucose |
| abstract | The present invention relates to a kind of RAFT method synthesis method containing the temperature sensitive copolymer of glucose, including: succinic acid divinyl ester and glucose are dissolved in solvent, add alkaline protease, under the conditions of 35～55 DEG C, stirring reaction 3 5d, obtain vinyl succinic acid glucose ester OVSG；OVSG and two polyethylene glycol monomethyl ethermethacrylic acid esters DEGMA is dissolved in solvent, adds initiator, chain-transferring agent, under 55 90 DEG C of oil bath nitrogen protections, react 8 15h, terminate reaction, purify, to obtain final product.The present invention uses RAFT method to synthesize the Thermo-sensitive copolymer Han glucose, and synthetic reaction carries out stable, implode will not occur, and reaction products therefrom molecular weight dispersion width is low；The method has simple to operate, effect outstanding feature；Gained copolymer micelle has biocompatibility, and toxicity is relatively low, can be widely used at biomedicine field. |
| priorityDate | 2014-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 36.