http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104045743-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C08B37-10 |
| filingDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104045743-B |
| titleOfInvention | A kind of preparation method of fine work dalteparin sodium |
| abstract | The present invention relates to a kind of preparation method of fine work dalteparin sodium, comprising: 1. degrade: heparin sodium is dissolved, regulate PH, add Sodium Nitrite, stir; 2. reduce: add hydroxide solution to stopping DeR, then add sodium borohydride reduction, regulate PH; 3. alcohol precipitation: carry out an alcohol precipitation and secondary alcohol precipitation successively with alcohol, obtains secondary alcohol precipitation lysate; 4. ultrafiltration: the ultra-filtration membrane being 10000 by secondary alcohol precipitation lysate molecular weight cut-off carries out ultrafiltration, when interior liquid is concentrated to 45% of original volume, stops ultrafiltration; 5. degerming; 6. freeze-drying.Adopt the dalteparin sodium that the inventive method obtains, its quality is apparently higher than EP current edition standards of pharmacopoeia, and heparin yield significantly improves, and method is simple.In addition, the method production used time is few, mild condition, and cost is low, and suitability for industrialized is produced, and has important application prospect. |
| priorityDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 37.