http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104043132-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-16 |
| filingDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-06-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104043132-B |
| titleOfInvention | A kind of multifunctional nano biomaterial transfection reagent with gene therapy Parkinson's disease effect and its preparation method and application |
| abstract | The invention provides a kind of multifunctional nano biomaterial transfection reagent with gene therapy Parkinson's disease effect and preparation method thereof.The method is that nerve growth factor (NGF) is fixed on the ferriferrous oxide nano grain (Fe of hydrogel parcel by the method for photo-grafting 3 O 4 -OA-NAPI-AA) surface, then adsorb the plasmid DNA that can interfere with alpha-synapse nucleoprotein synthesis.Described nano material transfection reagent is acted on MPP + External Parkinson's disease model PC12 cell after induction, the apoptosis of cell is subject to obvious suppression, wherein trk C (NGFR) up-regulated, alpha-synapse nucleoprotein down-regulated expression, have impact on BAX, the P53 of classics simultaneously, Bcl-2 apoptosis pathway, reaches the purpose for the treatment of Parkinson's disease.Nano material transfection reagent of the present invention is little without toxicity, side effect, can enter cell, effect substantially by carrying gene smoothly, be worthy of popularization in the treatment of Parkinson's disease. |
| priorityDate | 2014-06-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 94.