abstract |
The present invention relates to novel macrocyclic compounds useful as kinase inhibitors, in particular LRRK2 (Leucine Rich Repeat Kinase 2) inhibitors, and compositions containing said compounds. Furthermore, the present invention provides processes for the preparation of the disclosed compounds as well as methods for their use, for example as medicaments or diagnostic agents, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity, such as neurological disorders, Including Parkinson's disease and Alzheimer's disease. |