http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104016963-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 |
| filingDate | 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104016963-B |
| titleOfInvention | A kind of preparation method of 2,5-diamino-3,4-thiophene dicarboxylic acid ethyl ester derivative and purposes |
| abstract | The present invention relates to a kind of preparation method and purposes of 2,5-diamino-3,4-thiophene dicarboxylic acid ethyl ester derivative, this compounds, obtains with substituted benzaldehyde or fragrant heterocyclic aldehydes condensation for raw material with Sulfur and ethyl cyanacetate under the catalysis of triethylamine.Mtt assay is adopted synthesized compound to be carried out to the antitumor activity screening of human breast cancer cell (T47D, MCF-7), human cervical carcinoma cell (Hela), people's endometrial carcinoma cell (Ishikawa), experimental result shows: compound 1,2b, 2c, 2e, the 2h-2l inhibit activities to T47D cell strain is obvious; Compound 2a, 2b, 2c, 2h, the 2j restraining effect to MCF-7 is stronger; Compound 2j all shows very strong inhibit activities, for the IC of MCF-7, Hela and Ishikawa tri-kinds of JEG-3 to four kinds of JEG-3n 50 be respectively 2.4 μMs, 4.7 μMs and 7.6 μMs, all good with positive control drug Zorubicin.Preparation method's reaction conditions of the present invention is gentle, and experimental procedure is simple and direct. |
| priorityDate | 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 52.