http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104016963-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4d2edff2a09f26d9b6aabeb85262e8cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-38 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-12 |
| filingDate | 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_54ca952259a2b685698e3ecf9c036797 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e576a87672b81a287dba28e372e9ddf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cedcf69de824464bc7cb194687f808a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1036f19e6c024b713810adfe26713d21 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_238d884dea94bf530107e41636b16409 |
| publicationDate | 2014-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104016963-A |
| titleOfInvention | Preparation method and application of a kind of 2,5-diamino-3,4-thiophene dicarboxylate derivative |
| abstract | The present invention relates to a preparation method and application of ethyl 2,5-diamino-3,4-thiophene dicarboxylate derivatives, which use sulfur and ethyl cyanoacetate as raw materials, and are catalyzed by triethylamine It can be obtained by condensation with substituted benzaldehyde or aromatic heterocyclic aldehyde. The synthesized compound was screened for anti-tumor activity on human breast cancer cells (T47D, MCF-7), human cervical cancer cells (Hela), and human endometrial cancer cells (Ishikawa) by MTT method. The experimental results showed that the compound 1, 2b, 2c, 2e, 2h-2l have obvious inhibitory activity on T47D cell lines; compounds 2a, 2b, 2c, 2h, 2j have strong inhibitory effects on MCF-7; compound 2j has strong inhibitory activity on four cancer cell lines It showed strong inhibitory activity, and the IC 50 for the three cancer cell lines of MCF-7, Hela and Ishikawa were 2.4 μM, 4.7 μM and 7.6 μM, respectively, all better than the positive control drug doxorubicin. The preparation method adopted in the present invention has mild reaction conditions and simple and convenient experimental steps. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-112724157-A |
| priorityDate | 2014-06-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
| Predicate | Subject |
|---|---|
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2005073265-A1 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/substance/SID467867630 |
Total number of triples: 23.