| abstract |
A kind of 3,4-disubstituted pyrroles compounds, this compound has the structure shown in below formula: The preparation method of above-mentioned 3,4-disubstituted pyrroles compounds is to occur Michael addition, cyclization and elimination to react and obtain by disubstituted olefin with to Methyl benzenesulfonyl methyl isocyanide.Compared with prior art, a series of 3 the present invention relates to, 4-disubstituted pyrroles compounds has stronger anti tumor activity in vitro, Normocellular proliferation inhibition activity is suppressed very weak simultaneously, showing excellent tumor cells selectivity, future can as a class safely and effectively antitumor drug.The preparation method of the present invention is easy and simple to handle, and reaction time is short, and yield is higher. |