| abstract |
The invention provides a kind of construct, it includes the nucleotide sequence of (i) encoding tyrosine hydroxylase (TH), (ii) nucleotide sequence of coding GTP cyclization hydrolases I (CH1) nucleotide sequence and (iii) encoded aromatic amino acids DOP Adecarboxylase (AADC), wherein coding TH nucleotide sequence is connected with encoding CH1 nucleotide sequence so that their encoding fusion protein TH CH1.Present invention also offers the viral vector comprising the nucleotide sequence and its treat and/or prevent Parkinson's disease in purposes. |