http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-104003978-B
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-12 |
| filingDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-104003978-B |
| titleOfInvention | The industrialized process for preparing of bepotastine or its racemoid |
| abstract | This application provides the industrialized process for preparing of a kind of bepotastine or its racemoid, comprise the following steps: [4-[(S)-(4-chloro-phenyl-) (4-piperidyl oxygen base) methyl] pyridine or its raceme are dissolved in organic solvent by 2-; Add alkaline acid binding agent, 4-bromobutyrate, stirring is warming up to backflow and carries out condensation reaction; Cooling after terminating, filtration, organic layer concentrating under reduced pressure obtains oily matter; Add purified water stirring, extraction into ethyl acetate, separatory in oily matter, the organic layer alkali liquid washing obtained, drying, after filtering siccative, underpressure distillation obtains intermediate; In intermediate, add alkali lye hydrolysis, after completing, be adjusted to acidity, stir, filter, concentrated, add methylene dichloride stir, dry, again filter, concentrating under reduced pressure obtain bepotastine or its racemoid.Use the method that the application provides, operating process simplifies, and Reaction time shorten, racemization phenomenon can not occur, have output high, simple operation and other advantages. |
| priorityDate | 2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.