http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103992392-B
Outgoing Links
Predicate | Object |
---|---|
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-55 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-23 |
filingDate | 2014-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2017-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | CN-103992392-B |
titleOfInvention | A kind of solid phase synthesis process of Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2 |
abstract | The invention discloses a kind of Ac-D-2Nal-D-4Cpa-D-3Pal-Ser-4Aph(Hor)-D-4Aph(Cbm)-Leu-Lys(iPr)-Pro-D-Ala-NH2 and the synthetic method of raw material; with Fmoc amino resins as solid phase carrier; the whey acid fragment for replacing 5 bit aminos of phenylalanine phenyl ring 4 connected with ivdde; condensation reaction connects 10 amino acid of protection successively from C-terminal to N-terminal, obtains full guard peptide resin, then takes off the Fmoc protection groups of N-terminal D Nal; with acetic anhydride and pyridine acetylation; Hor in ivDde replacements is taken off, peptide resin is cut with lytic reagent, ice ether precipitation obtains thick peptide.Additionally, this patent is also related to the method for ivDde OH and Fmoc Aph OH synthesis material Fmoc Aph (ivDde) OH.The present invention first introduces ivDde synthesis decapeptides, replaces Hor again afterwards and avoids the generation for resetting side reaction, and processing step is simple, it is easy to control, small to human body and ambient influnence, yield is high, is adapted to large-scale production. |
priorityDate | 2014-05-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.