http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-103992317-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ac31afbea1cbbb03498644721ffb4a62 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 |
| filingDate | 2014-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d579a1ec47592b9b8bdd1917251858b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ad2ef6041ae30498f3964e4893352ca6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76d9d8653de4d8db994305a0ce696a02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d503207c6428e4774f80ae54d13fb43 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a6b6f22d720a318dde5d9dc894344f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0be6b91089a442a86a9037081b9d206f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fa95c56a1b4c48832b2c205b8ceaf42 |
| publicationDate | 2014-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | CN-103992317-A |
| titleOfInvention | A kind of synthetic method of 5-carbonitrile-pyrrole [1,2-a] quinoline derivative |
| abstract | The invention relates to a synthesis method of 5-formonitrile-pyrrole [1,2-a] quinoline, which uses 2-haloaryl acetonitrile and 2-formyl azole compounds as raw materials, and the ratio of substances is 1 to 2:1, take 2-formyl azole compound and 2-haloaryl acetonitrile dissolved in organic solvent, add copper salt, ligand, alkaline medium, stir at 80-120°C for 8-24 hours under the protection of inert gas to react to obtain 5-formonitrile-pyrrole [1,2-a] quinoline derivatives, after cooling, extraction, drying, and distillation under reduced pressure to obtain pure products. The invention has the following advantages: (1) the reaction conditions are relatively mild, the catalytic activity is high, the reaction yield is high up to 90%, the product selectivity is high, and the substrate expansion range is wide. (2) The catalytic system avoids the use of expensive ligands, reduces the reaction temperature, is low in cost, safe and convenient, and the reaction system has little environmental pollution. |
| priorityDate | 2014-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 28.